which of the following was a significant challenge in building the panama canal?\nmosquitoes spread diseases…

Brief Explanations:

Building the Panama Canal faced multiple challenges. Mosquito - borne diseases like malaria and yellow fever were a major issue. The tropical environment was conducive to mosquito breeding, and these diseases severely affected the workforce. Engineering plans were well - thought - out (the canal was eventually built successfully with the right engineering). There is no significant historical record of widespread strikes specifically for extra pay being a major, long - term challenge. Congress did provide funds, although there were financial considerations, but disease was a more critical and immediate challenge.

Answer:

Mosquitoes spread diseases to workers.