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directions: questions 6 is a short free - response questions that requires about 6 minutes to answer. the question is worth 3 points. read the question carefully and completely. answers must be written out in paragraph form. outlines, bulleted lists, or diagrams alone are not acceptable. figure 1. radioactively labeled polypeptides in an experiment investigating the mechanism of protein secretion, researchers tracked the movement of radioactively labeled polypeptides in pancreatic cells. at various times after the labeling, samples of the cells were analyzed using an electron microscope to determine the location of the radioactively labeled polypeptides. figure 1 summarizes the results at 5 minutes, 15 minutes, and 30 minutes. the dark dots in the figure represent the radioactively labeled polypeptides. (a) using the experimental results, describe the pathway that secretory proteins take from their synthesis to their release from the cell. note on your ap exam, you will handwrite your responses to free - response questions in a test
At 5 minutes, labeled polypeptides are in the endoplasmic reticulum (ER). By 15 minutes, they have moved to the Golgi apparatus. At 30 minutes, they are in secretory vesicles and being released from the cell. So the pathway is ER → Golgi → secretory vesicles → out of the cell.
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Secretory proteins are synthesized in the endoplasmic reticulum (ER), then move to the Golgi apparatus for modification and packaging, and are finally transported in secretory vesicles to be released from the cell.