Question

6 fill in the blank 1 point
total body clearance of a drug refers to the volume of plasma cleared of a drug per unit time. to indicate how clearance is calculated, select each part of the equation from the drop-downs below.
measure units
choose your answer... choose your answer.
clearance ml/min choose your answer...
(mg/ml)
(mg/min)
concentration of drug in plasma
rate of elimination
choose your answer.
7 multiple choice 1 point

Explanation:

Total body clearance of a drug is calculated using the formula: Clearance = $\frac{\text{Rate of elimination}}{\text{Concentration of drug in plasma}}$. The units align as follows: rate of elimination has units of (mg/min), plasma drug concentration has units of (mg/ml), so clearance units are $\frac{\text{mg/min}}{\text{mg/ml}}$ = ml/min, which matches the given clearance unit.

Answer:

• Measure (numerator): Rate of elimination
• Units (numerator): (mg/min)
• Measure (denominator): Concentration of drug in plasma
• Units (denominator): (mg/ml)

Clearance formula: $\text{Clearance} = \frac{\text{Rate of elimination}}{\text{Concentration of drug in plasma}}$