Question

scenario: a patient with alcohol use disorder and liver disease requires medication for treatment. question: which medication is preferred in patients with liver impairment? disulfiram. acamprosate. naltrexone. methadone.

Explanation:

To determine the preferred medication for a patient with alcohol use disorder and liver impairment, we analyze each option:

• Disulfiram: Can cause liver toxicity, so not preferred in liver impairment.
• Acamprosate: Is excreted renally (through the kidneys) and has minimal hepatic (liver) metabolism, making it a good choice for patients with liver impairment.
• Naltrexone: Undergoes hepatic metabolism, so its use may be limited or require dose adjustment in liver impairment.
• Methadone: Is primarily used for opioid use disorder, not as a first - line for alcohol use disorder in this context, and also has hepatic metabolism considerations.

Answer:

B. Acamprosate