QUESTION IMAGE
Question
- what are the checkpoints for cells, where in the cell cycle can they be found, and what are they checking for?
- cancer is caused by?
- what is the cell cycle?
- what are the parts of interphase and what occurs in each step?
- what are the functions of the cell cycle?
- what is mitosis?
- how is mitosis related to genetic continuity (continuity means \the same\)?
Question 9 (Cell Cycle Checkpoints)
There are three main cell cycle checkpoints: G₁, G₂, and M (spindle) checkpoint. The G₁ checkpoint is at the end of G₁ phase, checking if the cell has enough nutrients, growth factors, and if the DNA is undamaged to enter S phase. The G₂ checkpoint is at the end of G₂ phase, verifying DNA replication completeness and damage before mitosis. The M checkpoint (spindle checkpoint) occurs during metaphase of mitosis, ensuring chromosomes are properly attached to the spindle fibers before anaphase.
Cancer is caused by mutations (changes) in the DNA of cells, specifically in genes (like proto - oncogenes and tumor suppressor genes) that regulate the cell cycle. These mutations can lead to uncontrolled cell growth and division.
The cell cycle is a series of events that a cell goes through as it grows, replicates its DNA, and divides to produce two daughter cells. It includes interphase (G₁, S, G₂ phases) and the mitotic (M) phase (mitosis and cytokinesis).
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| Checkpoint | Location in Cell Cycle | Checking For |
|---|---|---|
| G₂ Checkpoint | End of G₂ phase (before mitosis) | Complete DNA replication, no DNA damage (to proceed to mitosis) |
| M (Spindle) Checkpoint | Metaphase of mitosis | Chromosomes properly attached to spindle fibers (to proceed to anaphase) |