Question

which drug inhibits antihypertensive activity when used concurrently with a nasal decongestant?
phenelzine
methyldopa
isocarboxazid
tranylcypromine

Explanation:

Methyldopa is an antihypertensive drug. When used concurrently with nasal decongestants (which are sympathomimetic drugs), it can inhibit the antihypertensive activity due to the vasoconstrictive effects of the nasal decongestants counteracting the blood - pressure - lowering effects of methyldopa. Phenelzine, Isocarboxazid, and Tranylcypromine are mono - amine oxidase inhibitors (MAOIs) and do not have the same specific interaction in terms of inhibiting antihypertensive activity with nasal decongestants as methyldopa does.

Answer:

Methyldopa