Question

which mutation would allow the cell to divide when it should not, and could possibly lead to cancer? multiple choice a mutation preventing p21 from dissociating from cyclin. a mutation preventing cyclin from interacting with cdk. a mutation causing p21 to remain active, even in the absence of a signal from p53. a mutation causing p53 to activate p21, even when it is not necessary. none of these will lead to cell proliferation.

Explanation:

p21 is a cyclin - dependent kinase inhibitor that regulates the cell cycle and prevents cell division. When p21 remains associated with cyclin, it inhibits the cyclin - CDK complex which is required for cell - cycle progression. If a mutation prevents p21 from dissociating from cyclin, it will keep inhibiting cell division. A mutation preventing cyclin from interacting with CDK also inhibits cell - cycle progression. A mutation causing p53 to activate p21 when not necessary or p21 to remain active without p53 signal will also halt cell division. These mutations act as tumor - suppressor mechanisms rather than promoting cell division.

Answer:

None of these will lead to cell proliferation.