Question

example, enzymes can help convert an extracellular signal into an
intracellular response. specifically, adenylyl cyclase is an enzyme that
catalyzes the conversion of atp to cyclic amp (camp).

one competitive inhibitor of adenylyl cyclase is called mant-itp.

which of the following questions would best direct an investigation on
how mant-itp impacts a signal transduction pathway?

choose 1 answer:

a how does mant-itp affect the binding of ligands to g protein-
coupled receptors?
b how does mant-itp affect the shape of g protein-coupled
receptors?
c how does mant-itp affect the response to intracellular signals?
d how does mant-itp affect the recognition of an extracellular
signal?

Explanation:

MANT - ITP is a competitive inhibitor of adenylyl cyclase, which is involved in converting ATP to cAMP (an intracellular signaling molecule). So, to investigate its impact on the signal transduction pathway, we should look at its effect on intracellular signal responses. Option A: MANT - ITP inhibits adenylyl cyclase, not directly related to ligand - G protein - coupled receptor binding. Option B: It doesn't affect the shape of G protein - coupled receptors as it targets adenylyl cyclase. Option D: It has no direct role in extracellular signal recognition. Option C focuses on the response to intracellular signals, which is relevant as adenylyl cyclase's product (cAMP) is an intracellular signal mediator.

Answer:

C. How does MANT - ITP affect the response to intracellular signals?