Question

in the first spanish colonies, how did nearly all indigenous peoples die?
poison
disease
sacrifice
neglect

Explanation:

Spanish colonizers brought pathogens like smallpox, measles, and influenza to the Americas. Indigenous populations had no prior exposure or immunity to these Eurasian diseases, leading to massive, widespread mortality that killed the vast majority of Indigenous peoples in early Spanish colonies. The other options were not the primary cause of near-total Indigenous death.

Answer:

disease