Question

question 6
1 pts
which receptor’s blockade is most likely responsible for the weight gain seen with many antipsychotic medications?
dopamine d2 receptor
histamine h1 receptor
muscarinic m1 receptor
serotonin 5-ht3 receptor

Explanation:

To determine the receptor whose blockade causes weight gain with antipsychotics, we analyze each option:

• Dopamine D2 receptor: Blockade of D2 is related to antipsychotic effects (e.g., reducing psychosis) but not primarily weight gain.
• Histamine H1 receptor: Blocking H1 receptors leads to increased appetite and subsequent weight gain, a common side - effect of many antipsychotics.
• Muscarinic M1 receptor: Blockade of M1 is associated with anticholinergic side - effects like dry mouth, blurred vision, not weight gain.
• Serotonin 5 - HT3 receptor: Blockade of 5 - HT3 is related to anti - emetic effects, not weight gain.

Answer:

B. Histamine H1 receptor