Question

which route should the nurse clarify with the healthcare provider prior to administering a drug with a high first-pass effect? oral. buccal. sublingual. intravenous.

Explanation:

Drugs with a high first - pass effect are significantly metabolized when taken orally (the drug passes through the liver before reaching systemic circulation, reducing its bioavailability). Buccal, sublingual, and intravenous routes bypass or minimize the first - pass effect (intravenous goes directly into the bloodstream, buccal and sublingual are absorbed through mucosal membranes and enter the systemic circulation without first - pass metabolism in the liver). So the nurse should clarify the oral route as it is affected by the first - pass effect.

Answer:

A. Oral