Question

which type of mutation causes sickle cell anemia?
silent
missense
insertion
frameshift

Explanation:

Sickle - cell anemia is caused by a single - base substitution in the gene for hemoglobin. This substitution changes the sixth amino acid in the beta - globin chain from glutamic acid (Glu) to valine (Val). A missense mutation is a point mutation that changes a single nucleotide, resulting in a codon that codes for a different amino acid. In sickle - cell anemia, the change in the amino acid leads to abnormal hemoglobin structure and function.

Answer:

B. missense