Question

a nurse is preparing to administer amphotericin b iv to a client who has a systemic fungal infection. which of the following medications should the nurse prepare to administer prior to the infusion to prevent or minimize adverse reactions? (select all that apply.)

aspirin

hydrocortisone

acetaminophen

diphenhydramine

ibuprofen

Explanation:

Amphotericin B often causes infusion-related reactions like fever, chills, rigors, and allergic responses. Hydrocortisone (a corticosteroid) reduces inflammatory and allergic reactions. Acetaminophen (an antipyretic/analgesic) prevents or treats infusion-related fever and discomfort. Diphenhydramine (an antihistamine) blocks histamine release to minimize allergic-type reactions like itching, rash, or bronchospasm. Aspirin and ibuprofen are not standard pre-medications here due to higher bleeding risk and lack of established benefit for these specific reactions.

Answer:

Hydrocortisone, Acetaminophen, Diphenhydramine