Question

a patient with a cough has a suspicious lung lesion, a mediastinal lymph mass, and several bone lesions. what test is indicated to determine histology and staging of this cancer?
biopsy of a bone lesion
bone marrow aspiration and biopsy
bronchoscopy with lung biopsy
thoracentesis and pleural fluid cytology

Explanation:

The patient has a suspicious lung lesion which is the primary - likely source. Bronchoscopy with lung biopsy can directly sample the lung tissue to determine the cancer's histology and also help in staging by assessing the local and mediastinal involvement. Biopsy of a bone lesion or bone marrow aspiration/biopsy would mainly focus on bone - related aspects rather than the primary lung source. Thoracentesis and pleural fluid cytology are more for pleural - related issues rather than the main tumor histology and staging in this case.

Answer:

Bronchoscopy with lung biopsy