Question

which issue is related to long-term heroin use?
○ pleasure
○ depression
○ hypoxia
○ mood swings

Explanation:

Long - term heroin use can lead to hypoxia. Heroin can depress the respiratory system, which in turn can cause a decrease in the amount of oxygen that reaches the tissues (hypoxia). Pleasure is a short - term effect of heroin use, not a long - term issue related to its use. While depression and mood swings can be associated with drug use, hypoxia is a more direct and characteristic long - term physiological consequence of long - term heroin use due to its impact on respiration.

Answer:

hypoxia