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- why does substance use increase the risk for suicide? answer: copyright goodheart - willcox co., inc. may not be posted to a publicly accessible website.
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Substance use can increase the risk for suicide through multiple mechanisms such as altering brain chemistry (e.g., disrupting neurotransmitter systems like serotonin which is involved in mood - regulation), causing psychological distress including anxiety and depression, impairing judgment and impulse control which can lead to impulsive self - harm behaviors, and social isolation due to substance - related problems which can exacerbate feelings of hopelessness.