Question

2 fill in the blank 1 point
match each of the pharmacokinetic characteristics below to the drug modality it is most likely associated with. note that each option may be used once, more than once, or not at all.
pharmacokinetic characteristic
some can induce permanent genetic changes after only one administration
metabolized by cytochrome p450 enzymes
primarily metabolized by proteolysis
metabolized by exo- and endonucleases
may be converted to active metabolites
following catabolism, monomeric subunits of this therapeutic modality are reused by the body
drug modality
choose your answer...
choose your answer...
nucleic acid therapeutics
neither
protein therapeutics
small molecule drugs
choose your answer...
3 multiple choice 1 point

Explanation:

1. Some can induce permanent genetic changes after only one administration: Nucleic acid therapeutics (e.g., gene therapies) alter genetic material long-term.
2. Metabolized by cytochrome P450 enzymes: Cytochrome P450s primarily metabolize small molecule drugs in the liver.
3. Primarily metabolized by proteolysis: Proteins are broken down by proteases, so this applies to protein therapeutics.
4. Metabolized by exo- and endonucleases: Nucleases specifically break down nucleic acids, matching nucleic acid therapeutics.
5. May be converted to active metabolites: Small molecule drugs often are prodrugs activated via metabolism; other modalities rarely use this mechanism.
6. Following catabolism, monomeric subunits of this therapeutic modality are reused by the body: Protein catabolism produces amino acids, which the body recycles for new protein synthesis.

Answer:

• Some can induce permanent genetic changes after only one administration: Nucleic acid therapeutics
• Metabolized by cytochrome P450 enzymes: Small molecule drugs
• Primarily metabolized by proteolysis: Protein therapeutics
• Metabolized by exo- and endonucleases: Nucleic acid therapeutics
• May be converted to active metabolites: Small molecule drugs
• Following catabolism, monomeric subunits of this therapeutic modality are reused by the body: Protein therapeutics