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module 2 exam 25 - 26 biology a / module 2: principles of inheritance 3. what keeps the two dna strands separate during replication? single strand binding proteins double strand binding proteins double strand binding saprophytes single strand binding phosphates
During DNA replication, single - strand binding proteins (SSBs) bind to the separated single - strands of DNA to prevent them from re - annealing (coming back together) and to protect them from nucleases. There are no such things as double - strand binding proteins, double - strand binding saprophytes, or single - strand binding phosphates that perform this function in DNA replication.
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single strand binding proteins