Question

what made the area unattractive for settlement?
the lack of trees and water
lack of buffalo
lack of business
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Explanation:

For an area to be attractive for settlement, basic resources like trees (for materials, shelter, etc.) and water (for drinking, agriculture, etc.) are crucial. Lack of buffalo is more about a specific resource for certain groups, and lack of business is a secondary factor compared to essential natural resources. So the lack of trees and water would make an area unattractive for settlement.

Answer:

the lack of trees and water (the checkbox next to "the lack of trees and water" should be selected)