Question

1 multiple choice 1 point why are small molecule drugs (smds) often the easiest drugs to administer? the general population is more familiar with the mechanisms of action of smds than other therapeutic modalities, and are therefore more likely to take them. many smds have a high volume of distribution, which means that a significant proportion of the administered drug will reach its molecular target. many smds can be administered orally, which does not require injection or the participation of a medical professional. many smds have high bioavailability, and can therefore be administered at a lower dose. 2 multiple choice 1 point what property of smds explains why they bind more unintended targets than protein therapeutics do? acid - base dissociation constant lipophilicity polarity size

Explanation:

Question 1

To determine why small molecule drugs (SMDs) are often the easiest to administer, we analyze each option:

• The first option is incorrect because the general population's familiarity with mechanisms of action is not a primary reason for ease of administration.
• The second option is incorrect as a high volume of distribution relates to how the drug spreads in the body, not ease of administration.
• The third option is correct. Oral administration is a key factor for ease as it doesn't require injections or medical professionals, making it convenient for patients.
• The fourth option is incorrect because high bioavailability and lower dose relate to drug efficacy and dosage, not ease of administration.

To find the property of SMDs that explains why they bind more unintended targets than protein therapeutics, we analyze each option:

• Acid - base dissociation constant relates to the drug's acidity or basicity, not non - specific binding.
• Lipophilicity is about the drug's affinity for lipids, not non - specific binding.
• Polarity is about the charge distribution of the molecule, not non - specific binding.
• Size: SMDs are small in size compared to protein therapeutics. Their small size allows them to fit into a wider variety of binding sites, including unintended ones, leading to more non - specific binding.

Answer:

C. Many SMDs can be administered orally, which does not require injection or the participation of a medical professional.

Question 2