Question

1 fill in the blank 1 point
match each of the pharmacokinetic characteristics below to the drug modality it is most likely associated with. note that each option may be used once, more than once, or not at all.

pharmacokinetic characteristic
reach systemic circulation upon oral administration
limited tissue distribution due to their large size
vulnerable to degradation by nucleases
can be excreted through the renal and biliary routes
vulnerable to degradation by proteases in the gi tract
can accumulate in cells of the renal proximal tubule instead of being freely excreted

drug modality
choose your answer...
choose your answer...
protein therapeutics
small molecule drugs
neither
nucleic acid therapeutics
choose your answer...

Explanation:

1. Reach systemic circulation upon oral administration: Small molecule drugs are small enough to cross intestinal barriers and enter the bloodstream orally.
2. Limited tissue distribution due to their large size: Protein therapeutics are large molecules, so they cannot easily cross most tissue barriers.
3. Vulnerable to degradation by nucleases: Nucleic acid therapeutics (like RNA/DNA) are broken down by nucleases, enzymes that target nucleic acids.
4. Can be excreted through the renal and biliary routes: Small molecule drugs are small enough to be filtered by the kidneys (renal) and secreted into bile (biliary) for excretion.
5. Vulnerable to degradation by proteases in the GI tract: Protein therapeutics are proteins, so they are broken down by proteases in the gastrointestinal tract.
6. Can accumulate in cells of the renal proximal tubule instead of being freely excreted: Protein therapeutics are taken up by renal proximal tubule cells rather than being filtered and excreted freely.

Answer:

• Reach systemic circulation upon oral administration: Small molecule drugs
• Limited tissue distribution due to their large size: Protein therapeutics
• Vulnerable to degradation by nucleases: Nucleic acid therapeutics
• Can be excreted through the renal and biliary routes: Small molecule drugs
• Vulnerable to degradation by proteases in the GI tract: Protein therapeutics
• Can accumulate in cells of the renal proximal tubule instead of being freely excreted: Protein therapeutics