Question

hemoglobin is a protein present in red blood cells. in the genetic disease sickle cell anemia, there is a mutation in the hbb gene that codes for the hemoglobin protein. the mutation results in hemoglobin proteins that clump together abnormally in cells. this leads to red blood cells that are sickled (crescent - shaped) rather than round. sickled cells are fragile and can cause damage to tissue throughout the body. how do changes in the hbb gene affect body function? place phrases into the table in the correct order to explain how changes in the hbb gene affect body tissue function.
step sequence of how changes in hbb gene affect body tissue function
1
2
3
4
mutation occurs in dna sequence
abnormally shaped amino acids form
mutation occurs during protein folding
abnormal sequence of amino acids forms
proteins that form are abnormal in shape and behavior
cell shape is irregular, resulting in abnormal cell and tissue function

Explanation:

1. First, a mutation occurs in the DNA sequence of the HBB gene.
2. This leads to an abnormal sequence of amino - acids forming as the gene is translated.
3. The proteins that form are abnormal in shape and behavior due to the abnormal amino - acid sequence.
4. Finally, the cell shape becomes irregular (sickled), resulting in abnormal cell and tissue function.

Answer:

1. Mutation occurs in DNA sequence
2. Abnormal sequence of amino acids forms
3. Proteins that form are abnormal in shape and behavior
4. Cell shape is irregular, resulting in abnormal cell and tissue function