Question

4 multiple choice 1 point ibuprofen and codeine are analgesic drugs in that both drugs treat mild to severe pain. ibuprofen is a weak acid and codeine is a weak base. when taken orally ibuprofen is more likely to be absorbed in an ____ environment and so is more easily absorbed in the __ as here it is ____ fat - soluble than codeine. options: alkaline; stomach; more; alkaline; intestines; more; alkaline; stomach; less; alkaline; intestines; less; acidic; stomach; more; acidic; intestines; more; acidic; stomach; less; acidic; intestines; less

Explanation:

1. First, recall the principle of drug absorption: Weak acids are more likely to be absorbed in acidic environments, and weak bases in alkaline environments. Ibuprofen is a weak acid, so it's more likely absorbed in an acidic environment.
2. The stomach has an acidic environment (due to HCl), while the intestines are more alkaline. So for ibuprofen (weak acid), the acidic stomach is the site for better absorption.
3. Ibuprofen, being a weak acid, in acidic environment (stomach) will be more non - ionized (since weak acids are less ionized in acidic pH, and non - ionized form is fat - soluble). Codeine is a weak base, so in acidic stomach, it will be more ionized (less fat - soluble). So ibuprofen is more fat - soluble than codeine in the stomach.

Answer:

E. acidic; stomach; more