Question

change in shape of an enzyme due to extremes in temperature of ph, causes the enzymes to stop functioning
base (alkaline)
denature
neutral
lock and key model

Explanation:

The question is about the term for the change in enzyme shape due to extreme temperature or pH that stops its function. "Denature" refers to this process, while "Base (alkaline)" is a pH type, "Neutral" is a pH level, and "Lock and Key Model" explains enzyme - substrate binding, not enzyme shape change due to extremes.

Answer:

B. Denature