Question

lysosomal storage diseases are a group of inherited diseases each caused by the inability of the lysosome to make a certain lysosomal enzyme. which statement best explains how a lysosomal storage disease may affect the cell?
a the cell cannot regulate its uptake and excretion of molecules.
b certain macromolecules accumulate to toxic levels within the cell.
c there is reduced atp production to fuel the cell’s metabolic needs.
d newly synthesized proteins cannot reach their correct destinations.

Explanation:

Lysosomes contain enzymes that break down macromolecules. If a lysosomal enzyme is missing (as in lysosomal storage diseases), the macromolecules that the enzyme should break down will not be degraded and will accumulate in the cell. Option A is incorrect because lysosomes aren't primarily for regulating uptake/excretion. Option C is incorrect as lysosomes don't produce ATP (mitochondria do). Option D is incorrect as lysosomes aren't involved in protein targeting (that's related to the Golgi and signal sequences). So the correct explanation is that certain macromolecules accumulate to toxic levels within the cell.

Answer:

B. Certain macromolecules accumulate to toxic levels within the cell.