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Question
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some chemotherapy drugs are antimitotic, because they interfere with the function of the spindle during mitosis. which event of mitosis is an antimitotic drug most likely to prevent?
a breakdown of the nuclear membrane
b separation of chromatids
c chromosome formation
d duplication of centrioles
Antimitotic drugs target the spindle apparatus. The spindle fibers attach to chromatids and pull them apart during anaphase of mitosis. Without functional spindles, chromatids cannot separate. The other events (nuclear membrane breakdown, chromosome formation, centriole duplication) do not directly depend on the spindle's function.
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B. separation of chromatids