Question

1. this pedigree shows the inheritance of cystic fibrosis in a family. this disease causes mucus to build up in the lungs, leading to breathing difficulty and infections

ff =
ff =
ff =
fill out the genotypes of each of the family members.
add to the chart to show the youngest male (4th) generation marrying and having a child with cf.

Explanation:

To solve the problem of determining the genotypes for cystic fibrosis (CF) inheritance, we use the principles of Mendelian genetics, specifically autosomal recessive inheritance (since CF is an autosomal recessive disorder).

Step 1: Recall CF Inheritance

Cystic fibrosis is caused by a recessive allele (\( f \)).:

• Homozygous dominant (\( FF \)): Does not have CF (no mutated alleles).
• Heterozygous (\( Ff \)): Carrier (has one mutated allele, does not have CF).
• Homozygous recessive (\( ff \)): Has CF (two mutated alleles).

Step 2: Assign Genotypes

Using the autosomal recessive inheritance pattern:

• \( FF \): Normal (no CF, no mutation).
• \( Ff \): Carrier (has one mutated allele, no CF).
• \( ff \): Has cystic fibrosis (two mutated alleles).

Answer:

• \( FF \): Normal (no CF)
• \( Ff \): Carrier (no CF, but carries the mutation)
• \( ff \): Has cystic fibrosis (CF)