Question

required information
mutated forms of the rb protein
multiple choice
bind to e2f thereby promoting uncontrolled cell division.
bind to e2f thereby inhibiting cell division.
bind to e2f but have no effect on cell division.
do not bind to e2f thereby inhibiting cell division.
do not bind to e2f thereby promoting uncontrolled cell division.

Explanation:

The normal Rb protein binds to E2F to inhibit cell - cycle progression and cell division. Mutated forms of Rb protein are unable to properly bind to E2F. Since E2F promotes cell - cycle progression and cell division, when Rb is mutated and can't bind E2F, it leads to uncontrolled cell division.

Answer:

bind to E2F thereby promoting uncontrolled cell division.