Question

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synthetic materials are made from natural materials that were changed in
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Explanation:

Synthetic materials are created by altering natural materials through chemical processes (reactions) to form new substances with different properties. The key here is recognizing that the change involves chemical reactions (or a chemical process) to transform natural materials into synthetic ones.

Answer:

chemical reactions (or "a chemical process" can also be acceptable, but "chemical reactions" is more precise for the context of material synthesis from natural materials)