Question

bone scans may be falsely negative in multiple myeloma because
please select your answer...
a the malignant cells suppress osteoblastic activity
b the malignant cells suppress osteoclastic activity
c the malignant cells increase osteoblastic activity
d the malignant cells increase osteoclastic activity

Explanation:

Bone scans rely on increased osteoblastic (bone-forming) activity to detect lesions, as the tracer used is taken up by active osteoblasts. In multiple myeloma, the malignant plasma cells primarily drive osteoclastic (bone-resorbing) activity while suppressing osteoblastic activity. With reduced osteoblastic function, the bone scan tracer is not taken up effectively, leading to false-negative results.

Answer:

A. the malignant cells suppress osteoblastic activity