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key points quiz from the caribbean to the carolinas answer these questions to check your understanding of english colonization from the caribbean to the carolinas. what were the major challenges of the colony... what were the major challenges of the colony in north carolina? multiple choice it lacked good harbors and rivers and thus a means of marketing its goods. its establishment led to problems with native americans, so it was plagued with violence for years. nobody wanted to move there since slavery and hard liquor were prohibited. slave uprisings left colonists in perpetual fear.
North - Carolina's colonial establishment led to conflicts with Native Americans due to land - grabs and cultural differences, resulting in years of violence. It had some harbors and rivers, slavery was present in the colony, and the liquor situation was not a major deterrent for settlement. Slave uprisings were not the main challenge compared to Native - American relations.
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It's establishment led to problems with Native Americans, so it was plagued with violence for years.