Question

14 multiple choice 1 point drug metabolism and excretion generally determine the ____ of a drug. mechanism of action therapeutic action duration of action site of action 15 multiple choice 1 point a drug that is being used to lower levels of ldl cholesterol in a patient belongs to the functional category of drugs used to __. replace inadequacies of naturally occurring substances treat infection or cancer alter mood or behavior change regulation 16 multiple choice 1 point the volume of distribution is an extrapolated volume, meaning that it is a theoretical value based on the concentration of drug in the ____ compartment. intracellular interstitial vascular lymphatic

Explanation:

Question 14

Drug metabolism (how the body processes the drug) and excretion (how the drug is removed from the body) affect how long the drug remains active in the body. The mechanism of action is about how the drug produces its effect, therapeutic action is the beneficial effect, and site of action is where the drug acts. So metabolism and excretion relate to how long the drug acts (duration of action).

Lowering LDL cholesterol involves regulating (changing regulation of) lipid levels. Replacing inadequacies is for things like hormone replacement, treating infection/cancer is for antimicrobials/chemotherapeutics, and altering mood/behavior is for psychotropic drugs. So a drug lowering LDL is for changing regulation (of lipid metabolism).

Volume of distribution ($V_d$) is calculated using the drug concentration in the plasma (vascular) compartment. Intracellular and interstitial are not the primary compartments for measuring drug concentration to calculate $V_d$. So the theoretical value is based on drug concentration in the vascular compartment.

Answer:

C. duration of action

Question 15