Question

based on the model, is it possible that princess alice will have a child with hemophilia?
a. yes, all of her children will likely have hemophilia.
b. yes, all of her daughters will likely have hemophilia.
c. no, none of her children will likely have hemophilia.
d. yes, if one of her children is male, he may have hemophilia.

Explanation:

Hemophilia is an X-linked recessive disorder. Princess Alice is a carrier (XᵣX, where Xᵣ is the recessive hemophilia allele, X is the normal allele). Her male partner has a normal genotype (XY). When they have children:

• For sons: They inherit the Y chromosome from the father, and either Xᵣ or X from Alice. There is a 50% chance a son inherits Xᵣ and develops hemophilia.
• For daughters: They inherit a normal X from the father, so even if they inherit Xᵣ from Alice, they will be carriers but not have hemophilia.

Options A, B, and C are incorrect because not all children, not all daughters, will have hemophilia, and it is possible for sons to have the disorder.

Answer:

D. Yes, if one of her children is male, he may have hemophilia.