Question

imagine you are able to genetically engineer a change in the gene of a membrane protein such that the signal sequence is completely removed. this engineered gene, when expressed, will make a protein that is most likely to end up in which location? smooth endoplasmic reticulum cytoplasm nucleus rough endoplasmic reticulum mitochondria

Explanation:

The signal sequence is crucial for targeting proteins to the endoplasmic - reticulum and other membrane - bound organelles. Without a signal sequence, the protein will not be directed to the endoplasmic reticulum (smooth or rough) or mitochondria. Proteins without signal sequences are typically translated on free ribosomes and remain in the cytoplasm.

Answer:

cytoplasm