Question

select the correct answer.
chronic myeloid leukemia (cml) is a genetic disorder associated with the philadelphia chromosome. the philadelphia chromosome is a mutation in chromosome 22. part of chromosome 22 is exchanged with part of chromosome 9, bringing together two genes on chromosome 22 and causing a malignancy. what type of mutation occurs in the philadelphia chromosome?
a. duplication
b. insertion
c. inversion
d. substitution
e. translocation

Explanation:

The question describes a genetic mutation where part of chromosome 22 is exchanged with part of chromosome 9. This type of mutation, where segments of non-homologous chromosomes are swapped, is a translocation. The other options do not match: duplication is extra copies of a segment, insertion adds a segment from another source, inversion reverses a segment within a chromosome, and substitution is a single base change.

Answer:

E. translocation