Question

use the diagram to answer the question.
sickle cell anemia
what type of mutation could have occurred to cause the disorder shown? (1 point)
options: (1) insertion (2) frameshift (3) deletion (4) substitution

Explanation:

To determine the mutation type, we analyze the DNA and amino acid sequences. In sickle cell anemia, the DNA triplet changes from GAG (coding for Glu) to GTG (coding for Val) in the hemoglobin gene, which is a single - base - pair substitution (point mutation). A missense mutation is a type of point mutation where a single nucleotide change results in a different amino acid being incorporated into the protein. Here, the normal amino acid Glu is replaced by Val, so it is a missense mutation. Frameshift mutations (insertion or deletion) would shift the reading frame, and deletion/insertion of multiple bases, which is not the case here.

Answer:

(1) missense (assuming the first option is missense, with the full option being like "A. missense" if there were option labels, but based on the context, the mutation type is missense)