Question

write your answers on a separate sheet of paper.

1. how does a person with one sickle - cell allele differ from a person with two sickle - cell alleles?

Explanation:

A person with one sickle-cell allele (heterozygous, genotype $Hb^A Hb^S$) has sickle cell trait. They typically have no or very mild symptoms, as most of their red blood cells are normal, and they have increased resistance to malaria. A person with two sickle-cell alleles (homozygous recessive, genotype $Hb^S Hb^S$) has sickle cell disease. Their body produces mostly abnormal, sickle-shaped red blood cells that can block blood vessels, causing severe pain, organ damage, anemia, and other serious health complications.

Answer:

A person with one sickle-cell allele (sickle cell trait) usually has no/mild symptoms and malaria resistance, while a person with two sickle-cell alleles has sickle cell disease, with severe symptoms like pain, organ damage, and anemia from abnormal sickle-shaped red blood cells.