Question

1. order: kaletra (lopinavir/ritonavir) 800/200 mg po daily. read the label in • figure 6.24. how many ml of this antiretroviral agent will you administer to the patient who has hiv infection?

• figure 6.24

drug label for kaletra.

1. order: metformin hydrochloride 750 mg po b.i.d. with meals. read the label in • figure 6.25. how many tablets of this antidiabetic drug will you administer to the patient?

• figure 6.25

drug label for metformin hcl.

1. order: phenobarbitol sodium 400 mg po in two divided doses daily. the recommended dosage of this anticonvulsant is 1–3 mg/kg/d. is the prescribed dose safe for the patient who weighs 203 pounds?
2. the physician orders detrol la (tolterodine tartrate) 4 mg po daily for a patient with an overactive bladder. read the label in • figure 6.26 and determine how many capsules you will give this patient.

• figure 6.26

drug label for detrol la.

1. a patient who has difficulty sleeping is medicated for insomnia with 0.25 g of a drug po at bedtime. the drug is available as 500 mg per scored tablet. how many tablets will you administer to your patient?
2. the physician orders coumadin (warfarin sodium) 6.5 mg po every other day from monday through sunday. how many milligrams of coumadin will your patient receive in the week?

Explanation:

Question 12

Step1: Identify dose per mL

Each mL has 80 mg lopinavir + 20 mg ritonavir (total 100 mg, matching 800/200 mg order ratio). Required total dose: 800/200 mg.

Step2: Calculate volume

Volume = $\frac{\text{Required lopinavir dose}}{\text{Lopinavir per mL}}$ = $\frac{800\ \text{mg}}{80\ \text{mg/mL}}$

Step1: Understand order

Order: 750 mg po b.i.d. (twice daily)

Step2: Match tablet strength

Tablet strength = 750 mg per tablet. Per dose: $\frac{750\ \text{mg}}{750\ \text{mg/tablet}}$ = 1 tablet. Daily: 1 × 2 = 2 tablets.

Step1: Calculate safe dose range

Patient weight = 203 pounds. Convert to kg: $203\ \text{lb} \times \frac{1\ \text{kg}}{2.2\ \text{lb}} \approx 92.27\ \text{kg}$
Safe daily dose range: $1\ \text{mg/kg/d} \times 92.27\ \text{kg} = 92.27\ \text{mg/d}$ to $3\ \text{mg/kg/d} \times 92.27\ \text{kg} = 276.81\ \text{mg/d}$

Step2: Compare to prescribed dose

Prescribed dose = 400 mg daily.

Answer:

$10\ \text{mL}$

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Question 13