Question

identify any possible contraindication(s) or caution(s) with atorvastatin calcium (lipitor)
name edward castellanos
id: 386 - 71222
date reviewed
include your initials.
medication name
brand & generic
dosage
strength & frequency
naproxen bid
erythromycin 10 days
atorvastatin calcium 20mg po qd
allergies
include reaction and date
medical history
arthritis (knees), peptic ulcer disease, diabetes, sinus infection (1/1/00)
none: the patient has no contraindications or cautions with atorvastatin calcium (lipitor)

Explanation:

Atorvastatin calcium is a statin - type lipid - lowering drug. Contraindications include active liver disease, pregnancy, and breastfeeding. Interactions with other drugs like erythromycin (a macrolide antibiotic) can increase the risk of muscle toxicity (rhabdomyolysis). Also, non - steroidal anti - inflammatory drugs (NSAIDs) like naproxen may increase the risk of liver enzyme elevation when used with atorvastatin. The patient has a history of arthritis and peptic ulcer disease, and is taking naproxen and erythromycin along with atorvastatin.

Answer:

There are potential contraindications and cautions. Erythromycin can interact with atorvastatin increasing the risk of rhabdomyolysis. Naproxen may increase the risk of liver enzyme elevation. Also, the patient's history of peptic ulcer disease may be a consideration as statins can sometimes cause gastrointestinal symptoms.