Question

multiple select question select all that apply which of the following are reasons muscles can become fatigued? (select all that apply.) lack of ach (acetylcholine) at neuromuscular junction lack of sodium in the sarcoplasm build up of lactic acid atp depletion excess of calcium in the sarcoplasm

Explanation:

Acetyl - choline (ACh) is needed for muscle contraction at the neuromuscular junction, so its lack can cause fatigue. Sodium is crucial for muscle action potential, but lack of sodium in sarcoplasm isn't a common direct cause of fatigue. Lactic acid build - up during anaerobic respiration can lower pH and cause fatigue. ATP is the energy source for muscle contraction, and its depletion leads to fatigue. Excess calcium in sarcoplasm can disrupt normal muscle function and contribute to fatigue.

Answer:

A. Lack of ACh (acetylcholine) at neuromuscular junction
C. Build up of lactic acid
D. ATP depletion
E. Excess of calcium in the sarcoplasm